 |
HCV-specific information
and prevention messages
should be provided to infected persons and individuals
at risk by trained personnel in public and private
health-care settings. Health-education materials
should include a) general information about HCV
infection; b) risk factors for infection, transmission,
disease progression, and treatment; and c) detailed
prevention messages appropriate for the population
being tested. Written materials might also include
information about community resources available for HCV-positive patients for medical evaluation and social
support, as appropriate.
Persons with High-Risk Drug and Sexual
Practices
Regardless of test results, persons who use illegal drugs
or have high-risk sexual practices or occupations should
be provided with information regarding how to reduce
their risk for acquiring bloodborne and sexually
transmitted infections or of potentially transmitting
infectious agents to others
Negative Test Results
If their exposure was in the past, persons who test
negative for HCV should be reassured.
Indeterminate Test Results
Persons whose HCV test results are indeterminate should be advised that the result is inconclusive, and
they should receive appropriate follow-up testing or
referral for further testing.
Positive Test Results
Persons who test positive should be provided with information regarding the need for a)
preventing further harm to their liver; b) reducing risks for
transmitting HCV to others; and c) medical evaluation
for chronic liver disease and possible treatment.
- To protect
their liver from further harm, HCV-
positive persons should be advised to
- not drink alcohol;
- not start
any new medicines, including over-the-counter and herbal medicines,
without checking with their doctor; and
- get
vaccinated against hepatitis A if liver
disease is found to be present.
- To reduce
the risk for transmission to others, HCV-positive persons should be advised to
- not donate blood, body
organs, other tissue,
or semen;
- not share toothbrushes,
dental appliances,
razors, or other personal-care articles that
might have blood on them; and
- cover cuts and sores on the
skin to keep
from spreading infectious blood or secretions.
- HCV-positive
persons with one long-term steady
sex partner do not need to change their sexual practices. They should
- discuss the risk, which is
low but not absent,
with their partner (If they want to lower the limited chance of spreading HCV to their
partner, they might decide to use barrier
precautions [e.g., latex condoms]); and
- discuss with their partner
the need for
counseling and testing.
- HCV-positive
women do not need to avoid
pregnancy or breastfeeding. Potential, expectant,
and new parents should be advised that
- approximately 5 out of every
100 infants born
to HCV-infected women become infected
(This occurs at the time of birth, and no
treatment exists that can prevent this from happening);
- infants infected with HCV at
the time of
birth seem to do very well in the first years
of life (More studies are needed to determine
if these infants will be affected by the infection
as they grow older);
- no evidence exists that mode
of delivery is
related to transmission; therefore,
determining the need for cesarean delivery
versus vaginal delivery should not be made
on the basis of HCV infection status;
- limited data regarding
breastfeeding indicate
that it does not transmit HCV, although HCV-positive mothers should consider
abstaining from breastfeeding if their nipples
are cracked or bleeding;
- infants born to HCV-positive
women should
be tested for HCV infection and if positive,
evaluated for the presence or development of chronic
liver disease
- if an HCV-positive woman has
given birth to
any children after the woman became infected
with HCV, she should consider having the
children tested.
- Other
counseling messages
- HCV is not spread by
sneezing, hugging, coughing, food or water, sharing eating
utensils or drinking glasses, or casual contact.
- Persons should not be
excluded from work,
school, play, child-care or other settings on
the basis of their HCV infection status.
- Involvement with a support
group might
help patients cope with hepatitis C.
- HCV-positive
persons should be evaluated
(by referral or consultation, if appropriate) for
presence or development of chronic liver disease including
- assessment for biochemical
evidence of
chronic liver disease;
- assessment for severity of
disease and possible treatment according to current practice
guidelines in consultation with, or by referral
to, a specialist knowledgeable in this area
- determination of need
for hepatitis A
vaccination.
NIH CONSENSUS
STATEMENT REGARDING MANAGEMENT OF HEPATITIS C
(EXCERPTED)
The NIH "Consensus Statement on Management of Hepatitis C" was based on data available in March
1997. Because of advances in the field of antiviral
therapy for chronic hepatitis C, standards of practice
might change, and readers should consult with
specialists knowledgeable in this area. For more
information, visit the National Institute of Diabetes
and Digestive and Kidney Diseases (NIDDK) website
at http://www.niddk.nih.gov/health/digest/pubs/chrnhepc/chrnhepc.htm
| Persons
Recommended for Treatment |
|
Treatment is recommended for patients with chronic hepatitis C who are at greatest risk
for progression to cirrhosis, as characterized by |
- persistently elevated ALT levels;
- detectable HCV RNA; and
- a liver biopsy indicating either portal
or bridging fibrosis or at least moderate degrees of
inflammation and necrosis.
|
| Persons for Whom Treatment
Is Unclear |
|
Included are |
- patients with compensated cirrhosis (without
jaundice, ascites, variceal hemorrhage, or encephalopathy);
- patients
with persistent ALT elevations, but
with less severe histologic changes (i.e., no fibrosis
and minimal necroinflammatory changes)
(In these patients, progression to cirrhosis is
likely to be slow, if at all; therefore, observation
and serial measurements of ALT and liver
biopsy every 3-5 years is an acceptable alternative
to treatment with interferon); and
- patients
aged <18 years or >60 years (note that interferon is not approved for patients aged
<18 years).
|
Persons for
Whom Treatment Is Not
Recommended |
|
Included are |
- patients
with persistently normal ALT values;
- patients
with advanced cirrhosis who might be
at risk for decompensation with therapy;
- patients
who are currently drinking excessive amounts of alcohol or who are injecting illegal
drugs (treatment should be delayed until these behaviors have been discontinued for
>6 months); and
- persons with major depressive illness,
cytopenias, hyperthyroidism, renal transplantation, evidence
of autoimmune disease, or who are pregnant.
|

|